Research Publications

Explore our scientific contributions and latest research findings

Filter by Category

2025

A NIR-II pulsed laser diode array for spectral photoacoustic imaging of deep tissue oxygenation

Vincely V.D., Dickerson M., Hawkins C., Bayer C.L.

Biomedical Optics Express

This study demonstrates a compact, low-cost spectral photoacoustic imaging (sPAI) system using microfabricated pulsed laser diodes (PLDs) operating in the NIR-II window. The PLD array achieved imaging depths over 4 cm and accurate hemoglobin oxygenation measurements up to 3.8 cm in vivo, validating its potential for clinically relevant, portable photoacoustic imaging applications.

Read Full Paper
2025

Photoacoustic imaging of rat kidney tissue oxygenation using second near-infrared wavelengths

Vincely V.D., Bayer C.L.

Journal of Biomedical Optics, Vol. 30, Issue 2

This study demonstrates that using second near-infrared (NIR-II, 950–1400 nm) wavelengths in spectral photoacoustic imaging significantly improves the accuracy of tissue oxygenation (sO₂) measurements compared to conventional NIR-I methods. By reducing spectral coloring and scattering effects, NIR-II imaging achieved about a 50% decrease in sO₂ estimation error in both phantom and in vivo kidney experiments, enabling deeper and more reliable tissue assessments.

Read Full Paper
2023

Functional Photoacoustic Imaging for Placental Monitoring: A Mini Review

Vincely V.D., Bayer C.L.

IEEE Trans Ultrason Ferroelectr Freq Control. , Vol. 70, Issue 12, pp. 1642-1650

This perspective highlights the emerging use of photoacoustic (PA) imaging to study placental anatomy and function, offering insights into both healthy and pathological pregnancies like preeclampsia. By leveraging its ability to visualize vascular and oxygenation changes, PA imaging holds significant potential for clinical translation and improving maternal–fetal health outcomes.

Read Full Paper
2019

Spectral photoacoustic imaging to estimate in vivo placental oxygenation during preeclampsia

Lawrence D.L., Escott M.E., Myers L., Intapad S., Lindsey S.H. & Bayer C.L.

Scientific Reports, Vol. 9, Issue 558

This study used spectral photoacoustic imaging to monitor placental oxygenation in a rat model of preeclampsia. Results showed a 12% drop in placental oxygen saturation two days after reduced uterine perfusion, with sustained hypoxia confirmed histologically through late gestation. These findings establish photoacoustic imaging as a powerful tool for tracking placental hypoxia and evaluating potential preeclampsia therapies.

Read Full Paper